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Research at St Andrews

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

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Author(s)

Ruth Bowness, Martin J Boeree, Rob Aarnoutse, Rodney Dawson, Andreas Diacon, Chacha Mangu, Norbert Heinrich, Nyanda E Ntinginya, Anke Kohlenberg, Bariki Mtafya, Patrick P J Phillips, Andrea Rachow, Georgette Plemper van Balen, Stephen H Gillespie

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Abstract

Objectives The relationship between cfu and Mycobacterial Growth Indicator Tube (MGIT) time to positivity (TTP) is uncertain. We attempted to understand this relationship and create a mathematical model to relate these two methods of determining mycobacterial load.

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Original languageEnglish
Pages (from-to)448-455
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume70
Issue number2
Early online date25 Oct 2014
DOIs
StatePublished - Feb 2015

    Research areas

  • TTP, M, Tuberculosis, TB

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