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The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

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Author(s)

Ruth Bowness, Martin J Boeree, Rob Aarnoutse, Rodney Dawson, Andreas Diacon, Chacha Mangu, Norbert Heinrich, Nyanda E Ntinginya, Anke Kohlenberg, Bariki Mtafya, Patrick P J Phillips, Andrea Rachow, Georgette Plemper van Balen, Stephen H Gillespie

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Abstract

Objectives The relationship between cfu and Mycobacterial Growth Indicator Tube (MGIT) time to positivity (TTP) is uncertain. We attempted to understand this relationship and create a mathematical model to relate these two methods of determining mycobacterial load.

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Original languageEnglish
Pages (from-to)448-455
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume70
Issue number2
Early online date25 Oct 2014
DOIs
Publication statusPublished - Feb 2015

    Research areas

  • TTP, M, Tuberculosis, TB

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