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The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups: dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony

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DOI

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The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups : dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony. / Bennett, Kimberley Ann; Fedak, Mike; Moss, Simon E W ; Pomeroy, Patrick; Speakman, John R ; Hall, Ailsa Jane.

In: Journal of Experimental Biology, Vol. 216, No. 6, 15.03.2013, p. 984-991.

Research output: Contribution to journalArticle

Harvard

Bennett, KA, Fedak, M, Moss, SEW, Pomeroy, P, Speakman, JR & Hall, AJ 2013, 'The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups: dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony' Journal of Experimental Biology, vol. 216, no. 6, pp. 984-991. https://doi.org/10.1242/jeb.077438

APA

Bennett, K. A., Fedak, M., Moss, S. E. W., Pomeroy, P., Speakman, J. R., & Hall, A. J. (2013). The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups: dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony. Journal of Experimental Biology, 216(6), 984-991. https://doi.org/10.1242/jeb.077438

Vancouver

Bennett KA, Fedak M, Moss SEW, Pomeroy P, Speakman JR, Hall AJ. The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups: dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony. Journal of Experimental Biology. 2013 Mar 15;216(6):984-991. https://doi.org/10.1242/jeb.077438

Author

Bennett, Kimberley Ann ; Fedak, Mike ; Moss, Simon E W ; Pomeroy, Patrick ; Speakman, John R ; Hall, Ailsa Jane. / The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups : dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony. In: Journal of Experimental Biology. 2013 ; Vol. 216, No. 6. pp. 984-991.

Bibtex - Download

@article{592535b5b6dc46b4abff6cd853b045ad,
title = "The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups: dexamethasone stimulates mass loss and protein utilisation, but not departure from the colony",
abstract = "Seals must manage their energy reserves carefully while they fast on land to ensure that they go to sea with sufficient fuel to sustain them until they find food. Glucocorticoids (GCs) have been implicated in the control of fuel metabolism and termination of fasting in pinnipeds. Here we tested the hypothesis that dexamethasone, an artificial GC, increases fat and protein catabolism, and induces departure from the breeding colony in wild, fasting grey seal pups. A single intramuscular dose of dexamethasone completely suppressed cortisol production for 24–72 h, demonstrating activation of GC receptors. In experiment 1, we compared the effects of a single dose of dexamethasone or saline administered 10 days after weaning on fasting mass and body composition changes, cortisol, blood urea nitrogen (BUN) and glucose levels, and timing of departure from the colony. In experiment 2, we investigated the effects of dexamethasone on short-term (5 days) changes in mass loss, body composition and BUN levels. In experiment 1, dexamethasone induced a short-lived increase in mass loss, but there was no difference in timing of departure between dexamethasone- and saline-treated pups (N=10). In experiment 2, dexamethasone increased protein and water loss and prevented a decrease in BUN levels (N=11). Our data suggest changes in cortisol contribute to regulation of protein catabolism in fasting seal pups, irrespective of the sex of the animal, but do not terminate fasting. By affecting the rate of protein depletion, lasting changes in cortisol levels could influence the amount of time seal pups have to find food, and thus may have important consequences for their survival.",
keywords = "cortisol , body composition, deuterium dilution",
author = "Bennett, {Kimberley Ann} and Mike Fedak and Moss, {Simon E W} and Patrick Pomeroy and Speakman, {John R} and Hall, {Ailsa Jane}",
note = "This work was supported by a UK Natural Environment Research Council studentship.",
year = "2013",
month = "3",
day = "15",
doi = "10.1242/jeb.077438",
language = "English",
volume = "216",
pages = "984--991",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The role of glucocorticoids in naturally fasting grey seal (Halichoerus grypus) pups

T2 - Journal of Experimental Biology

AU - Bennett, Kimberley Ann

AU - Fedak, Mike

AU - Moss, Simon E W

AU - Pomeroy, Patrick

AU - Speakman, John R

AU - Hall, Ailsa Jane

N1 - This work was supported by a UK Natural Environment Research Council studentship.

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Seals must manage their energy reserves carefully while they fast on land to ensure that they go to sea with sufficient fuel to sustain them until they find food. Glucocorticoids (GCs) have been implicated in the control of fuel metabolism and termination of fasting in pinnipeds. Here we tested the hypothesis that dexamethasone, an artificial GC, increases fat and protein catabolism, and induces departure from the breeding colony in wild, fasting grey seal pups. A single intramuscular dose of dexamethasone completely suppressed cortisol production for 24–72 h, demonstrating activation of GC receptors. In experiment 1, we compared the effects of a single dose of dexamethasone or saline administered 10 days after weaning on fasting mass and body composition changes, cortisol, blood urea nitrogen (BUN) and glucose levels, and timing of departure from the colony. In experiment 2, we investigated the effects of dexamethasone on short-term (5 days) changes in mass loss, body composition and BUN levels. In experiment 1, dexamethasone induced a short-lived increase in mass loss, but there was no difference in timing of departure between dexamethasone- and saline-treated pups (N=10). In experiment 2, dexamethasone increased protein and water loss and prevented a decrease in BUN levels (N=11). Our data suggest changes in cortisol contribute to regulation of protein catabolism in fasting seal pups, irrespective of the sex of the animal, but do not terminate fasting. By affecting the rate of protein depletion, lasting changes in cortisol levels could influence the amount of time seal pups have to find food, and thus may have important consequences for their survival.

AB - Seals must manage their energy reserves carefully while they fast on land to ensure that they go to sea with sufficient fuel to sustain them until they find food. Glucocorticoids (GCs) have been implicated in the control of fuel metabolism and termination of fasting in pinnipeds. Here we tested the hypothesis that dexamethasone, an artificial GC, increases fat and protein catabolism, and induces departure from the breeding colony in wild, fasting grey seal pups. A single intramuscular dose of dexamethasone completely suppressed cortisol production for 24–72 h, demonstrating activation of GC receptors. In experiment 1, we compared the effects of a single dose of dexamethasone or saline administered 10 days after weaning on fasting mass and body composition changes, cortisol, blood urea nitrogen (BUN) and glucose levels, and timing of departure from the colony. In experiment 2, we investigated the effects of dexamethasone on short-term (5 days) changes in mass loss, body composition and BUN levels. In experiment 1, dexamethasone induced a short-lived increase in mass loss, but there was no difference in timing of departure between dexamethasone- and saline-treated pups (N=10). In experiment 2, dexamethasone increased protein and water loss and prevented a decrease in BUN levels (N=11). Our data suggest changes in cortisol contribute to regulation of protein catabolism in fasting seal pups, irrespective of the sex of the animal, but do not terminate fasting. By affecting the rate of protein depletion, lasting changes in cortisol levels could influence the amount of time seal pups have to find food, and thus may have important consequences for their survival.

KW - cortisol

KW - body composition

KW - deuterium dilution

UR - http://jeb.biologists.org/content/216/6/984.full.pdf?ijkey=Vstfsvd76MfNjff&keytype=finite

U2 - 10.1242/jeb.077438

DO - 10.1242/jeb.077438

M3 - Article

VL - 216

SP - 984

EP - 991

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

IS - 6

ER -

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ID: 47723597