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The X files: ''The mystery of X chromosome instability in Alzheimer's disease''

Research output: Contribution to journalReview article

Author(s)

Vladan P. Bajic, Mugbubah Essak, Lada Zivkovic, Alan J. Stewart, Sonja Zafirovic, Vladimir Bajic, Takashi Gojobori, Esma Isenovic, Biljana Spremo-Potparevic

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Abstract

Many years have passed from the discovery that a genetic component on chromosome 21 is the fundamental cause of early-onset, but also to the late onset of Alzheimer’s disease (LOAD). In the genetic sense, only the apolipoprotein E4 gene is found to be a risk factor for LOAD. Genetic risk assessment has not changed fundamentally in recent years despite the hypothesis that many additional unidentified genes are likely playing a role in AD development. In this review, we elaborate the role of X chromosome epigenetics in the controversial findings from genome-wide association studies of the protocadherin 11 gene and hypothesize that the other genetic risk factors may be based on X-chromosome epigenetics in AD.
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Details

Original languageEnglish
JournalFrontiers in Genetics
Publication statusAccepted/In press - 13 Dec 2019

    Research areas

  • X chromosome, Alzheimer's disease, Sex chromosome dosage, protocadherin 11, centromere instabiility

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