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Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

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Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. / Sobczak, Amelie Isabelle Sylvie; Stefanowicz, Fiona; Pitt, Samantha Jane; Ajjan, Ramzi A.; Stewart, Alan James.

In: BioMetals, Vol. 32, No. 1, 02.2019, p. 123-138.

Research output: Contribution to journalArticle

Harvard

Sobczak, AIS, Stefanowicz, F, Pitt, SJ, Ajjan, RA & Stewart, AJ 2019, 'Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes' BioMetals, vol. 32, no. 1, pp. 123-138. https://doi.org/10.1007/s10534-018-00167-z

APA

Sobczak, A. I. S., Stefanowicz, F., Pitt, S. J., Ajjan, R. A., & Stewart, A. J. (2019). Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. BioMetals, 32(1), 123-138. https://doi.org/10.1007/s10534-018-00167-z

Vancouver

Sobczak AIS, Stefanowicz F, Pitt SJ, Ajjan RA, Stewart AJ. Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. BioMetals. 2019 Feb;32(1):123-138. https://doi.org/10.1007/s10534-018-00167-z

Author

Sobczak, Amelie Isabelle Sylvie ; Stefanowicz, Fiona ; Pitt, Samantha Jane ; Ajjan, Ramzi A. ; Stewart, Alan James. / Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. In: BioMetals. 2019 ; Vol. 32, No. 1. pp. 123-138.

Bibtex - Download

@article{4af1f1ffff4342458de9699a1c5c9900,
title = "Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes",
abstract = "Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management.",
keywords = "Diabetes, HbA1c, ICP-MS, Metal homeostasis, Zinc/copper ratio",
author = "Sobczak, {Amelie Isabelle Sylvie} and Fiona Stefanowicz and Pitt, {Samantha Jane} and Ajjan, {Ramzi A.} and Stewart, {Alan James}",
note = "This work was supported by the British Heart Foundation (grant codes: PG/15/9/31270 and FS/15/42/31556).",
year = "2019",
month = "2",
doi = "10.1007/s10534-018-00167-z",
language = "English",
volume = "32",
pages = "123--138",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

AU - Sobczak, Amelie Isabelle Sylvie

AU - Stefanowicz, Fiona

AU - Pitt, Samantha Jane

AU - Ajjan, Ramzi A.

AU - Stewart, Alan James

N1 - This work was supported by the British Heart Foundation (grant codes: PG/15/9/31270 and FS/15/42/31556).

PY - 2019/2

Y1 - 2019/2

N2 - Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management.

AB - Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management.

KW - Diabetes

KW - HbA1c

KW - ICP-MS

KW - Metal homeostasis

KW - Zinc/copper ratio

U2 - 10.1007/s10534-018-00167-z

DO - 10.1007/s10534-018-00167-z

M3 - Article

VL - 32

SP - 123

EP - 138

JO - BioMetals

T2 - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 1

ER -

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ID: 257066696