Skip to content

Research at St Andrews

Treatment of uncomplicated UTI in males: a systematic review of the literature

Research output: Contribution to journalLiterature reviewpeer-review


Karen Farrell, Meera Tandan, Virginia Hernandez Santiago, Ildiko Gagyor, Anja Maria Braend, Marius Skow, Ingvild Vik, Filip Jansaaker, Gail Hayward, Akke Vellinga

School/Research organisations


Background Urinary tract infections (UTIs) affect around 20% of the male population in their lifetime. The incidence of UTIs in men in the community is 0.9–2.4 cases per 1000 aged <55 years and 7.7 per 1000 aged ≥85 years.

Aim To evaluate the outcomes of randomised controlled trials (RCTs) comparing the effectiveness of different antimicrobial treatments and durations for uncomplicated UTIs in adult males in outpatient settings.

Method A systematic literature review of RCTs of adult male patients with an uncomplicated UTI treated with oral antimicrobials in any outpatient setting. The outcomes were symptom resolution within 2 weeks of starting treatment, duration until symptom resolution, clinical cure, bacteriological cure, and frequency of adverse events.

Results From the 1052 abstracts screened, three provided sufficient information on outcomes. One study compared trimethoprim-sulfamethoxazole for 14 days (21 males) with 42 days (21 males). Fluoroquinolones were compared in the two other RCTs: lomefloxacin (10 males) with norfloxacin (11 males), and ciprofloxacin for 7 days (19 males) and 14 days (19 males). Combining the results from the three RCTs shows that for 75% males with a UTI (76/101) bacteriological cure was reported at the end of the study. Of the 59 patients receiving a fluoroquinolone, 57 (97%) reported bacteriological and clinical cure within 2 weeks after treatment.

Conclusion The evidence available is insufficient to make any recommendations in relation to type and duration of antimicrobial treatment for male UTIs. Sufficiently powered RCTs are needed to identify best treatment type and duration for male UTIs in primary care.



Original languageEnglish
Number of pages9
JournalBJGP Open
Issue number2
Early online date26 Apr 2021
Publication statusPublished - Apr 2021

    Research areas

  • Males, Urinary Tract Infections, Antibiotic treatment, Primary care, Randomised clinical trial, Review

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy

    Fraile Navarro, D., Sullivan, F., Azcoaga-Lorenzo, A. & Hernandez Santiago, V., 3 Jun 2020, In: BMJ Open. 10, 6, 4 p., e033424.

    Research output: Contribution to journalArticlepeer-review

  2. Use of an electronic clinical decision support system in primary care to assess inappropriate polypharmacy in young seniors with multimorbidity: Observational, descriptive, cross-sectional study

    MULTIPAP group, Aragon MultiPAP Group, Madrid MultiPAP Group: Marta Alcaraz-Borrajo, Lopez-Rodriguez, J. A., Sanz-Cuesta, T., Aza-Pascual-Salcedo, M., Bujalance-Zafra, M. J., Cura-Gonzalez, I., Hernández-Santiago, V., Rico-Blázquez, M., Tello-Bernabé, M. E. & Rumayor-Zarzuelo, M., 3 Mar 2020, In: Journal of Medical Internet Research. 8, 3, 10 p., e14130.

    Research output: Contribution to journalArticlepeer-review

  3. Changes in resistance among coliform bacteraemia associated with a primary care antimicrobial stewardship intervention: a population-based interrupted time series study

    Hernandez-Santiago, V., Davey, P. G., Nathwani, D., Marwick, C. A. & Guthrie, B., 7 Jun 2019, In: PLoS Medicine. 16, 6, 19 p., e1002825.

    Research output: Contribution to journalArticlepeer-review

  4. Exploring the training and scope of practice of GPs in England, Germany and Spain

    Glonti, K., Struckmann, V., Alconada, A., Pettigrew, L. M., Hernandez-Santiago, V., Minue, S., Risso-Gill, I., McKee, M. & Legido-Quigley, H., Mar 2019, In: Gaceta Sanitaria. 33, 2, p. 148-155

    Research output: Contribution to journalArticlepeer-review

  5. Short-course versus long-course therapy of the same antibiotic for community-acquired pneumonia in adolescent and adult outpatients

    López-Alcalde, J., Rodriguez-Barrientos, R., Redondo-Sánchez, J., Muñoz-Gutiérrez, J., Molero García, J. M., Rodríguez-Fernández, C., Heras-Mosteiro, J., Marin-Cañada, J., Casanova-Colominas, J., Azcoaga-Lorenzo, A., Hernandez Santiago, V. & Gómez-García, M., 6 Sep 2018, (E-pub ahead of print) In: Cochrane Database of Systematic Reviews. 9, 37 p., CD009070.

    Research output: Contribution to journalReview articlepeer-review

Related by journal

  1. Recording COVID-19 consultations: review of symptoms, risk factors, and proposed SNOMED CT terms

    Jani, B. D., Pell, J. P., McGagh, D., Liyanage, H., Kelly, D., de Lusignan, S., Weatherburn, C. J., Burns, R., Sullivan, F. M. & Mair, F. S., Oct 2020, In: BJGP Open. 4, 4, p. 1-10 10 p.

    Research output: Contribution to journalArticlepeer-review

  2. Connecting primary care patients to community-based physical activity: a qualitative study of health professional and patient views

    Carstairs, S. A., Rogowsky, R. H., Cunningham, K. B., Sullivan, F. & Ozakinci, G., 21 Jul 2020, (E-pub ahead of print) In: BJGP Open. Latest Articles, 13 p.

    Research output: Contribution to journalArticlepeer-review

  3. Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study

    Jammeh, E. A., Carroll, C. B., Pearson, S. W., Escudero, J., Anastasiou, A., Zhao, P., Chenore, T., Zajicek, J. & Ifeachor, E., 12 Jun 2018, In: BJGP Open. 2, 2, 13 p., bjgpopen18X101589.

    Research output: Contribution to journalArticlepeer-review

ID: 272337439