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Tuning the Nitric Oxide release from CPO-27 MOFs

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Author(s)

Damiano Cattaneo, Stewart James Warrender, Morven Jane Duncan, Christopher Kelsall, Mary Doherty, Phillip Whitfield, Ian Megson, Russell Edward Morris

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Abstract

Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.
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Original languageEnglish
Pages (from-to)14059-14067
JournalRSC Advances
Volume6
Issue number17
Early online date26 Jan 2016
DOIs
Publication statusPublished - 2016

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