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Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Research output: Contribution to journalArticle

Author(s)

Charlotte H. Hulme, Emma L. Wilson, Heidi R. Fuller, Sally Roberts, James B. Richardson, Pete Gallacher, Mandy J. Peffers, Sally L. Shirran, Catherine H. Botting, Karina T. Wright

School/Research organisations

Abstract

Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternative or individualised therapies can be offered. We previously used label-free quantitation (LF) with a dynamic range compression proteomic approach to assess the synovial fluid (SF) of ACI responders and non-responders. However, we were able to identify only a few differentially abundant proteins at baseline. In the present study, we built upon these previous findings by assessing higher-abundance proteins within this SF, providing a more global proteomic analysis on the basis of which more of the biology underlying ACI success or failure can be understood.
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Details

Original languageEnglish
Article number87
Number of pages17
JournalArthritis Research & Therapy
Volume20
DOIs
Publication statusPublished - 2 May 2018

    Research areas

  • Autologous chondrocyte implantation (ACI), iTRAQ proteomics, Label-free quantitation proteomics, Synovial fluid, Cartilage repair, Complement C1S subcomponent, Matrix metalloproteinase 3, MMP3

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