Skip to content

Research at St Andrews

Upconverting nanorockers for intracellular viscosity measurements during chemotherapy

Research output: Contribution to journalArticle


Open Access Status

  • Embargoed (until 16/09/20)


Paloma Rodríguez-Sevilla, Francisco Sanz-Rodríguez, Raúl P. Peláez, Rafael Delgado-Buscalioni, Liangliang Liang, Xiaogang Liu, Daniel Jaque

School/Research organisations


Chemicals capable of producing structural and chemical changes on cells are used to treat diseases (e.g., cancer). Further development and optimization of chemotherapies require thorough knowledge of the effect of the chemical on the cellular structure and dynamics. This involves studying, in a noninvasive way, the properties of individual cells after drug administration. Intracellular viscosity is affected by chemical treatments and it can be reliably used to monitor chemotherapies at the cellular level. Here, cancer cell monitoring during chemotherapeutic treatments is demonstrated using intracellular allocated upconverting nanorockers. A simple analysis of the polarized visible emission of a single particle provides a real-time readout of its rocking dynamics that are directly correlated to the cytoplasmic viscosity. Numerical simulations and immunodetection are used to correlate the measured intracellular viscosity alterations to the changes produced in the cytoskeleton of cancer cells by anticancer drugs (colchicine and Taxol). This study evidences the possibility of monitoring cellular properties under an external chemical stimulus for the study and development of new treatments. Moreover, it provides the biomedical community with new tools to study intracellular dynamics and cell functioning.


Original languageEnglish
Article number1900082
JournalAdvanced Biosystems
Issue number10
Early online date16 Sep 2019
Publication statusPublished - 15 Oct 2019

    Research areas

  • Cancer, In vitro chemotherapy, Rheometry, Upconverting nanoparticles

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Upconverting materials for boosting the development of advanced optical microrheometric techniques

    Rodríguez-Sevilla, P., Labrador-Páez, L. & Haro-González, P., Oct 2018, In : Optical Materials. 84, p. 514-523 10 p.

    Research output: Contribution to journalArticle

  2. The temperature of an optically trapped, rotating microparticle

    Rodriguez Sevilla, P., Arita, Y., Liu, X., Jaque, D. & Dholakia, K., 9 Sep 2018, In : ACS Photonics. 5, 9, p. 3772-3778

    Research output: Contribution to journalArticle

Related by journal

  1. Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes

    Morton, A., Murawski, C., Deng, Y., Keum, C., Miles, G. B., Tello, J. A. & Gather, M. C., Mar 2019, In : Advanced Biosystems. 3, 3, 8 p., 1800290.

    Research output: Contribution to journalArticle

ID: 261241947