Skip to content

Research at St Andrews

Visible light-promoted Fe-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow

Research output: Contribution to journalArticle

Author(s)

Xiao-Jing Wei, Irini Abdiaj, Carlo Sambiagio, Chenfei Li, Eli Zysman-Colman, Jesús Alcázar, Timothy Noël

School/Research organisations

Abstract

A continuous-flow, visible light-promoted method has been developed to overcome the limitations of Fe-catalyzed Kumada-Corriu cross-couplings. A variety of strongly electron-rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature, in high yields and within a few minutes residence time, considerably enhancing the applicability of this Fe-catalyzed reaction. The robustness of this protocol was demonstrated on the multi-gram scale, providing the potential for future pharmaceutical application.
Close

Details

Original languageEnglish
Pages (from-to)13030-13034
Number of pages6
JournalAngewandte Chemie International Edition
Volume58
Issue number37
Early online date11 Jul 2019
DOIs
Publication statusPublished - 9 Sep 2019

    Research areas

  • Cross-coupling, Iron catalysis, Photocatalysis, Kumada coupling, Flow chemistry

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. High-triplet-energy bipolar host materials based on phosphine oxide derivatives for efficient sky-blue thermally activated delayed fluorescence organic light-emitting diodes with reduced roll-off

    Kim, J. U., Wong, M. Y., Kumar, S., Hayes, O., Duncan, F., Chan, C-Y., Wong, B. Y-W., Ye, H., Cui, L-S., Nakanotani, H., Zysman-Colman, E. & Adachi, C., Oct 2019, In : Chemistry Letters. 48, 10, p. 1225-1228

    Research output: Contribution to journalArticle

  2. A tale of two tables

    Gil, M. P. & Zysman-Colman, E., Sep 2019, In : Nature Chemistry. 11, 9, p. 757-759 3 p.

    Research output: Contribution to journalEditorial

  3. Conjugated, rigidified bibenzimidazole ancillary ligands for enhanced photoluminescence quantum yields of orange/red-emitting iridium(III) complexes

    Henwood, A. F., Antón-García, D., Morin, M., Rota Martir, D., Cordes, D. B., Casey, C., Slawin, A. M. Z., Lebl, T., Buehl, M. & Zysman-Colman, E., 14 Jul 2019, In : Dalton Transactions. 48, 26

    Research output: Contribution to journalArticle

Related by journal

  1. High iso aldehyde selectivity in the hydroformylation of short-chain alkenes

    Iu, L., Fuentes, J. A., Janka, M., Fontenot, K. J. & Clarke, M. L., 11 Feb 2019, In : Angewandte Chemie International Edition. 58, 7, p. 2120-2124

    Research output: Contribution to journalArticle

  2. Metal-organic framework-activated carbon composite materials for the removal of ammonia from contaminated airstreams

    McHugh, L. N., Terracina, A., Wheatley, P. S., Buscarino, G., Smith, M. W. & Morris, R. E., 17 Jul 2019, In : Angewandte Chemie International Edition. Early View

    Research output: Contribution to journalArticle

  3. Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J. L., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. G. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie - International Edition. 58, 34, p. 11681-11685 5 p.

    Research output: Contribution to journalArticle

ID: 259377844

Top