Skip to content

Research at St Andrews

Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Author(s)

Birgit De Smet, Derek S Sarovich, Erin P Price, Mark Mayo, Vanessa Theobald, Chun Kham, Seiha Heng, Thong Phe, Matthew T G Holden, Julian Parkhill, Sharon J Peacock, Brian G Spratt, Jan Jacobs, Peter Vandamme, Bart J Currie

School/Research organisations

Abstract

Burkholderia pseudomallei isolates with shared multilocus sequence types (STs) have not been isolated from different continents. We identified two STs shared between Australia and Cambodia. Whole-genome analysis revealed substantial diversity within STs, correctly identified the Asian or Australian origin, and confirmed that these shared STs were due to homoplasy.

Close

Details

Original languageEnglish
Pages (from-to)323-326
JournalJournal of Clinical Microbiology
Volume53
Issue number1
Early online date12 Nov 2014
DOIs
StatePublished - Jan 2015

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Anti-microbial resistance in atopic dermatitis: need for an urgent rethink

    Harkins, C. P., Holden, M. T. G. & Irvine, A. D. 29 Nov 2018 In : Annals of Allergy Asthma & Immunology. In press

    Research output: Contribution to journalArticle

  2. Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes

    Zapotoczna, M., Riboldi, G. P., Moustafa, A. M., Dickson, E., Narechania, A., Morrissey, J. A., Planet, P. J., Holden, M. T. G., Waldron, K. J. & Geoghegan, J. A. 16 Oct 2018 In : mBio. 9, 5, 15 p., e00550-18

    Research output: Contribution to journalArticle

  3. The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients

    Harkins, C. P., McAleer, M. A., Bennett, D., McHugh, M., Fleury, O. M., Pettigrew, K. A., Oravcová, K., Parkhill, J., Proby, C. M., Dawe, R. S., Geoghegan, J. A., Irvine, A. D. & Holden, M. T. G. 24 Jul 2018 In : British Journal of Dermatology. Early View, 8 p.

    Research output: Contribution to journalArticle

  4. Gene exchange drives the ecological success of a multi-host bacterial pathogen

    Richardson, E. J., Bacigalupe, R., Harrison, E. M., Weinert, L. A., Lycett, S., Vrieling, M., Robb, K., Hoskisson, P. A., Holden, M. T. G., Feil, E. J., Paterson, G. K., Tong, S. Y. C., Shittu, A., van Wamel, W., Aanensen, D. M., Parkhill, J., Peacock, S. J., Corander, J., Holmes, M. & Fitzgerald, J. R. 23 Jul 2018 In : Nature Ecology and Evolution. 2, p. 1468-1478

    Research output: Contribution to journalArticle

  5. Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility

    Krishna, A., Holden, M. T. G., Peacock, S. J., Edwards, A. M. & Wigneshweraraj, S. 20 Jul 2018 In : Microbiology. Latest Article

    Research output: Contribution to journalArticle

Related by journal

  1. Development of a multilocus sequence typing scheme for the molecular typing of Mycoplasma pneumoniae

    Brown, R. J., Holden, M., Spiller, O. B. & Chalker, V. J. Oct 2015 In : Journal of Clinical Microbiology. 53, 10, p. 3195-3203

    Research output: Contribution to journalArticle

  2. Micro-evolution of Burkholderia pseudomallei during an acute infection

    Limmathurotsakul, D., Holden, M. T. G., Coupland, P., Price, E. P., Chantratita, N., Wuthiekanun, V., Amornchai, P., Parkhill, J. & Peacock, S. J. 2014 In : Journal of Clinical Microbiology.

    Research output: Contribution to journalArticle

  3. Multiplex PCR Assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12

    Bossé, J. T., Li, Y., Angen, O., Weinert, L. A., Chaudhuri, R. R., Holden, M. T., Williamson, S. M., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., Langford, P. R., BRaDP1T Consortium & Holden, M. Jul 2014 In : Journal of Clinical Microbiology. p. 2380-2385 6 p.

    Research output: Contribution to journalArticle

  4. Tools for detection of Mycoplasma amphoriforme: a primary respiratory pathogen?

    Ling, C. L., Oravcova, K., Beattie, T. F., Creer, D. D., Dilworth, P., Fulton, N. L., Hardie, A., Munro, M., Pond, M., Templeton, K., Webster, D., Workman, S., McHugh, T. D. & Gillespie, S. H. Apr 2014 In : Journal of Clinical Microbiology. 52, 4, p. 1177-1181 5 p.

    Research output: Contribution to journalArticle

ID: 159052645